Modeling Suggests Later Starting Age and 3-Year Intervals for Colonoscopy in MSH6 and PMS2

Modeling Suggests Later Starting Age and 3-Year Intervals for Colonoscopy in MSH6 and PMS2

Colorectal

Douglas K. Rex, MD, M�� reviewing Kastrinos F, et al. Gastroenterology 2021 Apr 8.

Lynch syndrome is associated with increased cancer risk, particularly in the colorectum, as a result of germline mutations in any of 4 mismatch repair genes designated MLH1, MSH2, MSH6, and PMS2. The risk of colorectal cancer is lower in MSH6 and PMS2 compared to MLH1 and MSH2.

In a modeling study, the optimal surveillance strategy for each mismatch repair gene was annually beginning at age 25 for MLH1, biennially from age 25 for MSH2, every 3 years starting at age 35 for MSH6, and every 3 years beginning at age 40 for PMS2.

Comment:

These results support increasingly discussed recommendations to begin colonoscopy surveillance later in MSH6 and PMS2 Lynch syndrome, with surveillance every 3 years as optimal.

Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.

Douglas K. Rex, MD, M��

Bio and Disclosures

Citation(s):

Kastrinos F, Ingram MA, Silver ER, et al. Gene-specific variation in colorectal cancer surveillance strategies for Lynch syndrome. Gastroenterology 2021 Apr 8. (Epub ahead of print) ()

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Modeling Suggests Later Starting Age and 3-Year Intervals for Colonoscopy in MSH6 and PMS2

Comment:

Citation(s):

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